I've already mentioned a few ways the germ-phobic can keep their computers from becoming breeding grounds for bacteria. These have generally involved washable keyboards and mice, but the pickings have been slim -- particularly frustrating if you're picky about your peripherals.
While I'm still waiting for a washable split-style ergonomic keyboard, Unotron still opens up the field a bit with wired and wireless washable keyboards, some of which have removable wrist rests. They take the same approach with their washable optical mice, most of which feature scroll wheels, and one of which is wireless. Best of all that cleanliness comes without a premium: prices for the keyboards range between $55 and $95, while the mice run from $55 to $84.