10. Sarah Kerrigan (a.k.a. Zerg Queen) - StarCraft
Originally an expendable Terran psychic spy/assassin (sheesh, that’s a mouthful), Sarah Kerrigan was a tragic figure in the StarCraft series who ultimately rose to become one hell of a supervillain.
Kerrigan was abandoned on a mission as the insectoid – and not to mention grotesque – race of Zerg closed in. She was captured and subsequently turned into a powerful half-bug/half-human hybrid while retaining her psychic abilities and eventually took over leadership of the Zerg population.
Even with a cockroach appearance that makes you want to grab the nearest thick-soled shoe, Kerrigan is still a foxy minx and the StarCraft universe would not have been nearly as exciting without her presence. Many StarCraft fans are captured by her bad-ass attitude even if she is the evil mama to a swarm of Zerglings capable of unleashing hell on the Koprulu Sector.